Psychosis is a psychiatric disorder that pertains to an abnormal mental state of a person characterized by a patient’s loss of contact with reality, during which the patient experiences hallucinations, delusions and imagined things that he thinks are very much real. Glucose psychosis is the type of psychosis that is often associated with diabetes which is primarily attributed to the deficiency of Glucose-6-phosphate dehydrogenase (G6PD).

A 2003 study by Alberto Bocchetta, initially shows the relationship of (G6PD) deficiency with acute psychosis, catatonic schizophrenia, and bipolar disorders. His findings potentially showed evidence linking diabetes with episodes of psychosis. Bocchetta’s study showed that aforementioned psychiatric disorders can directly be associated with glucose-6-phosphate dehydrogenase, a cytosolic enzyme in the pentose phosphate pathway for maintaining the nicotinamide adenine dinucleotide phosphate (NADPH), which in turn regulates the glutathione in cells that protects red blood cells from oxidative damage. Theoxidative damage of the blood is essentially what triggers psychosis because of the deficient supply of oxygen in the nerves and brains that induces hallucination and delusions.

Since diabetes causes inhibition of glucose-6-phosphate dehydrogenase, diabetic people experience deficiency of Glucose-6-phosphate dehydrogenase, which in turn triggers episodes of pyschosis. Thus, diabetic patients with extremely low blood sugar, tend to experience Psychotic episodes. This is typically manifested in the highly aroused and suddenly perked up personality of a diabetic person suffering low sugar levels. Corollary to which, the study also tends to suggest that controlling the blood sugar level of people would in turn help control psychosis separately of the antipsychotic medication.

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