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Glycemic Control Reduces CVD Risk

A recent report in the European Heart Journal, showed no significant difference between the mortality rate of ischemic heart disease (IHD) patients with diabetes and good long-term glycemic control compared to those without diabetes.

Dr. Ane C. Dale of the Norwegian University of Science and Technology in Norway conducted a 20-year follow-up study on the mortality from IHD of 205 patients with newly diagnosed diabetes and another 205 matched subjects without diabetes.

Using annual measurements of HbA1c, the researchers closely monitored the blood glucose control among the diabetics. The results show that the adjusted hazard ratio for death from IHD was 1.8 times higher in diabetic patients compared to non-diabetic subjects.

“The risk for death from IHD was four times higher in diabetic subjects with HbA1c in the highest quartile (hazard ratio 4.2) compared to the control group,” Dr. Dale noted, “Analyzing HbA1c as a continuous time-varying variable showed 30% (HR 1 .3) higher risk per increment of HbA1c among diabetes patients without known cardiovascular disease at baseline.”

The study findings are”compatible with the hypothesis that good glucose control reduces the risk of coronary complications in patients with diabetes.” Dr. Dale recommends good glycemic control in persons with newly diagnosed diabetes. She also stressed the need to control other cardiovascular risk factors properly.

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