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Diabetes Treatment in a New and Different Light

Most often, low blood sugar and weight gain are two main concerns of patients with type 2 diabetes. For a time the only solution has been injecting insulin to normalize blood sugar level. “Hypoglycemia is the most difficult obstacle in the management of blood sugar in people with diabetes;’ said Dr. Phillip Cryer, a professor of Endocrinology and Metabolism at Washington University School of Medicine in St. Louis.

And because diabetes is a complex disease, optimal disease control is solely not addressed by injecting insulin. Dr. Harold E. Lebovitz, professor of Medicine at the State University of New York observed, “Indeed, emerging evidence suggests the importance of an additional therapeutic target: GI (Gastrointestinal) hormone regulation”.

Januvia (Sitagliptin phosphate) works by generating the release of incretin hormones. This hormone produced in the gastrointestinal (GI) tract is responsible in activating the production of insulin in the body and slowing the rate of absorption in the GI tract. It triggers the body to naturally produce insulin that is needed in the body. At the same time, it slows down the emptying of the stomach to limit food intake.

“Incretin therapy offers an alternative option to currently available hypoglycemic agents for non-pregnant adults with type 2 diabetes with modest efficacy and a favorable weight change profile”, remarked Dr. Renee E. Amori of Tufts-New England Medical Center in Boston, based on the analysis of 29 studies he and his colleagues conducted.

Moreover, one big advantage of Januvia (Sitagliptin phosphate) over injected insulin is that it is taken orally. Aside from this, it works with the body in such a way that when the body’s blood sugar level rises, it immediately triggers the production of insulin.

“For the millions of Americans with type 2 diabetes, who continue to have inadequate blood sugar control, the approval of Januvia marks an important advance in the fight against diabetes… We now have another new option that treats the disease in an entirely new way that can be added to existing treatment regimens to help patients gain more control over their blood sugar levels”, declared Dr. Steven Galson, director of Food and Drug Administration’s Center for Drug Evaluation and Research in the United States.

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