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ACE Inhibitor plus Diuretic

Posted on March 25, 2018 | No Comments on ACE Inhibitor plus Diuretic

According to the ADVANCE (Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation) study, intake of two blood pressure (BP) lowering drugs may cut the risk of kidney disease by 20 percent. This is applicable even in patients who don’t have high blood pressure.
As published in the Journal of the American Society of Nephrology, the study divided 11,140 type 2 diabetics and hypertensive participants into two groups. The first group took the the angiotensin-converting enzyme (ACE), inhibitor perindopril and the diuretic drug indapamide, while the other group received inactive placebos.

Results show that 20% had normal BP below 130/80. “This research demonstrated that lowering blood pressure with an ACE inhibitor/diuretic combination prevents kidney complications, and even cause some early manifestations of kidney disease to resolve in people with diabetes regardless of whether their blood pressure is normal or elevated,” said Vlado Perkovic, MBBS, PhD, of The George Institute for International Health in Sydney, Australia, one of the study authors.

Four years later, a follow-up study showed that the rate of kidney disease was 21 % lower for patients on the combination drug therapy. Also, in some patients who previously had early signs of diabetes related kidney disease, kidney function returned to normal during treatment.

The drug combination also reduced kidney disease events even in patients who did not initially have high blood pressure. According to the study, the lower the BP level, the lower the risk of kidney disease even at blood pressures below the currently accepted normal level (130/80 mm Hg). ADVANCE was funded by grants from Servier and the National Health and Medical Research Council of Australia.

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